Preferred Label : Type-1 Polarized Dendritic Cell-induced Antigen-specific Autologous Cytotoxic T Lymphocytes;
NCIt synonyms : Autologous DC1-CTL; Type-1 Polarized DC-induced Antigen-specific Autologous CTLs; DC1-induced Antigen-specific Autologous CTLs;
NCIt definition : A preparation of autologous cytotoxic T-lymphocytes (CTL), specifically reactive to
melanoma-associated antigen 3 (MAGE-3), MAGE-4, survivin, human epidermal growth factor
receptor 2 (HER2; ERBB2) and cyclooxygenase-2 (COX-2), with potential immunomodulating
activity. Peripheral blood mononuclear cells (PBMCs) are collected from the patient.
Subsequently, autologous dendritic cells (DCs) are separated, treated with a certain
combination of cytokines to produce polarized type-1 DCs (DC1), and then are loaded
with MAGE-3/MAGE-4/survivin/HER2/COX-2 CTL epitope peptides. In turn, autologous CTLs
are collected, exposed ex vivo to the antigen-loaded DC1s and subsequently expanded
in vitro. Upon re-infusion of the DC1-induced MAGE-3/MAGE-4/survivin/HER2/COX-2-specific
autologous CTLs, the CTLs target and lyse tumor cells expressing the tumor-associated
antigens (TAAs). Exposure to DC1s generates more potent CTLs and thus induces a more
potent CTL response against TAA-expressing tumor cells. The targeted TAAs play key
roles in cellular proliferation and are overexpressed by a variety of cancer cell
types.;
NCI Metathesaurus CUI : CL512380;
Origin ID : C128892;
UMLS CUI : C4288083;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
