Autologous Neoantigen-specific T-lymphocytes GEN-011

Preferred Label : Autologous Neoantigen-specific T-lymphocytes GEN-011;

NCIt synonyms : Autologous Neoantigen-targeting T-cells GEN-011; Autologous Immunogenic Neoantigen-specific T-cells GEN-011;

NCIt definition : A preparation of autologous, personalized, immunogenic and tumor neoantigen-specific T-lymphocytes, with potential immunostimulating and antineoplastic activities. Tumor-specific neoantigen targets of autologous CD4 and/or CD8 T-cells are identified and T-cells that target immunogenic and stimulatory neoantigens are expanded ex vivo. Upon administration, the autologous neoantigen-specific T-lymphocytes GEN-011 recognize and bind to tumor cells expressing the targeted neoantigens, resulting in a cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient's tumor cells.;

Molecule name : GEN 011; GEN-011;

NCI Metathesaurus CUI : CL1648118;

Details

Origin ID

C178447;

UMLS CUI

C5555040;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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