" /> Axalimogene Filolisbac - CISMeF





Preferred Label : Axalimogene Filolisbac;

NCIt synonyms : Attenuated Live Listeria Encoding Human Papilloma Virus 16 E7 Vaccine; Lm-LLO-E7; Attenuated Live Listeria Encoding HPV 16 E7 Vaccine; Lovaxin-C; ADXS11-001 Vaccine;

NCIt definition : A cancer vaccine containing a live-attenuated strain of the bacterium Listeria monocytogenes (Lm) encoding human papillomavirus (HPV) type 16 E7 fused to a non-hemolytic listeriolysin O protein with potential immunostimulatory and antineoplastic activities. Upon vaccination with axalimogene filolisbac, Listeria expresses the HPV 16 E7 antigen and activates the immune system to mount a cytotoxic T-lymphocyte (CTL) response against cancer cells expressing HPV 16 E7. This may result in tumor cell lysis. In addition, the Listeria vector itself may induce a potent immune response. HPV 16 E7, a cell surface glycoprotein and tumor associated antigen, is overexpressed in the majority of cervical cancer cells.;

UNII : NY7PTD1862;

CAS number : 1587258-09-0;

Molecule name : ADXS11-001;

NCI Metathesaurus CUI : CL384120;

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02/05/2025


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