NCIt synonyms : Attenuated Live Listeria Encoding Human Papilloma Virus 16 E7 Vaccine; Lm-LLO-E7; Attenuated Live Listeria Encoding HPV 16 E7 Vaccine; Lovaxin-C; ADXS11-001 Vaccine;
NCIt definition : A cancer vaccine containing a live-attenuated strain of the bacterium Listeria monocytogenes
(Lm) encoding human papillomavirus (HPV) type 16 E7 fused to a non-hemolytic listeriolysin
O protein with potential immunostimulatory and antineoplastic activities. Upon vaccination
with axalimogene filolisbac, Listeria expresses the HPV 16 E7 antigen and activates
the immune system to mount a cytotoxic T-lymphocyte (CTL) response against cancer
cells expressing HPV 16 E7. This may result in tumor cell lysis. In addition, the
Listeria vector itself may induce a potent immune response. HPV 16 E7, a cell surface
glycoprotein and tumor associated antigen, is overexpressed in the majority of cervical
cancer cells.;
UNII : NY7PTD1862;
CAS number : 1587258-09-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1587258-09-0
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