Preferred Label : IL13Ralpha2-specific Hinge-optimized 4-1BB-co-stimulatory CAR/Truncated CD19-expressing
Autologous TN/MEM Cells;
NCIt synonyms : IL13 [EQ]BBzeta/truncated CD19[t] Naive and Memory T Cells; IL13 [EQ]BBzeta/truncated CD19[t] TN/MEM Cells; IL13Ra2-specific-hinge-optimized-4-1BB-CAR/truncated CD19-expressing Autologous TN/MEM
Lymphocytes;
NCIt definition : A preparation of ex vivo expanded, genetically modified autologous naïve and memory
T-cells (TN/MEM) transduced with a replication incompetent, self-inactivating (SIN)
lentiviral vector expressing a hinge-optimized, chimeric antigen receptor (CAR) specific
for interleukin-13 receptor alpha 2 (IL13Ra2), and containing the cluster of differentiation
137 (CD137; 4-1BB) co-stimulatory signaling domain fused to the signaling domain of
the T-cell antigen receptor complex zeta chain (CD3-zeta), and a truncated form of
human cluster of differentiation 19 (CD19t), with potential immunostimulating and
antineoplastic activities. Upon intratumoral or intracavitary administration, IL13Ra2-specific
hinge-optimized 4-1BB-co-stimulatory CAR/truncated CD19-expressing autologous TN/MEM
cells are directed to, and induce selective toxicity and cytolysis in, IL13Ra2-expressing
tumor cells. IL13Ra2, overexpressed by a variety of tumor cell types, is associated
with increased proliferation, migration and invasiveness of tumor cells. The co-stimulatory
signaling domain enhances both proliferation of T-cells and antitumor activity. Hinge
optimization prevents the recognition and clearance of the CAR by endogenous Fc receptors
(FcRs). CD19t is used as a surface marker to both track and quantify the modified
T-cells in vivo.;
NCI Metathesaurus CUI : CL539488;
Origin ID : C141460;
UMLS CUI : C4683836;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
