NCIt synonyms : Autologous CAR-20/19-T Cells; Anti-CD19/CD20 CAR Autologous T-lymphocytes;
NCIt definition : Autologous T-lymphocytes that have been transduced with a lentiviral vector to express
a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv)
of anti-CD19 in tandem with an anti-CD20 scFv, and coupled to the cytoplasmic portion
of the zeta chain of the human T-cell receptor (CD3zeta), and the co-stimulatory molecule
4-1BB (CD137), with potential immunostimulating and antineoplastic activities. Upon
transfusion, anti-CD19-CD20-CAR-CD3zeta-4-1BB-expressing autologous T-lymphocytes
recognize and direct T-cells to CD19- or CD20-expressing tumor B-cells. This results
in a cytotoxic T-lymphocyte (CTL) response against CD19- or CD20-expressing tumor
cells, and causes tumor cell lysis. Both CD19 and CD20 are B-cell-specific cell surface
antigens overexpressed in B-cell lineage malignancies.;