Preferred Label : Autologous Prostate Stem Cell Antigen-specific CAR T Cells BPX-601;
NCIt synonyms : Autologous PSCA-Specific Chimeric Antigen Receptor Engineered T Cells BPX-601; GoCART BPX-601; iMC/PSCA-zeta CAR BPX-601; Autologous PSCA-specific CAR T Cells BPX-601;
NCIt definition : A preparation of autologous T-lymphocytes expressing a chimeric antigen receptor (CAR)
consisting of an anti-human prostate stem cell antigen (PSCA) scFv (single chain variable
fragment) coupled to the zeta chain of the T-cell receptor (TCRzeta) and a drug-induced
co-stimulatory molecule, composed of an inducible, chimeric MyD88/CD40 (inducible
MC; iMC) co-stimulatory domain, in which both the MyD88 and CD40 lack their extracellular
domains, with potential antineoplastic activity. Upon administration of BPX-601, the
T-cells target and bind to PSCA-expressing cancer cells. Upon subsequent administration
of the chemical inducer of dimerization (CID) agent rimiducid, this agent targets
and binds to the drug binding domain, which leads to iMC expression, activation of
both CD40- and MyD88-mediated signal transduction pathways, and an induction of selective
cytotoxicity in, and eradication of PSCA-expressing cancer cells. iMC activation by
rimiducid increases T-cell survival and anti-tumor activity of the administered T-cells,
compared to T-cells without the drug iMC activation-switch. As these T-cells are engineered
to only be fully activated by binding to both antigen and rimiducid, T-cell proliferation,
activity and toxicity can be controlled by adjusting the dose of rimiducid, thereby
preventing uncontrolled T-cell activation which increases the safety of the administered
T-cells. PSCA is a glycosylphosphatidylinositol (GPI)-anchored cell surface antigen
overexpressed in many cancer cell types.;
Molecule name : BPX-601;
NCI Metathesaurus CUI : CL507925;
Origin ID : C128031;
UMLS CUI : C4287778;
Semantic type(s)
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
