NCIt definition : A preparation of autologous T-lymphocytes that are genetically modified with a lentiviral
vector encoding a T-cell receptor (TCR) specific for the tumor-associated antigen
(TAA) preferentially expressed antigen in melanoma (PRAME) and a CD8alphabeta (CD8ab)
co-receptor, with potential immunostimulating and antineoplastic activities. Upon
administration back into the patient, the autologous anti-PRAME TCR/CD8ab-expressing
T-cells IMA203CD8 specifically recognize and bind to PRAME expressed on cancer cells,
which induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against the
PRAME-expressing cancer cells. PRAME is overexpressed by a variety of cancer cell
types. Co-expression of the CD8ab heterodimer may enhance anti-tumor immune response
by engaging CD4 T-cells.;