NCIt definition : Genetically modified autologous T-lymphocytes transduced with a replication incompetent
retroviral vector expressing a chimeric T cell antigen receptor (CAR) consisting of
an anti-CD19 scFv (single chain variable fragment), fused to the extracellular, transmembrane
and intracellular signaling domains of the T cell co-stimulatory receptor CD28 and
the cytoplasmic signaling domain of the zeta chain of the TCR/CD3 complex (CD3-zeta)
(CAR19-28z), with potential antineoplastic activities. Upon intravenous administration,
autologous CD19-28z CAR-expressing T-lymphocytes are directed to CD19-expressing tumor
cells, which induces selective toxicity in CD19-expressing tumor cells. CD19 antigen
is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.
The CD28 co-stimulatory molecule signaling domain enhances activation and signaling
after recognition of CD19. The inclusion of the CD28 signaling domain may increase
proliferation of T-cells and antitumor activity compared to the inclusion of the CD3-zeta
chain alone.;