NCIt definition : A vaccine composed of phosphorylated peptides from the tumor associated antigens breast
cancer anti-estrogen resistance-3 (BCAR3) and insulin receptor substrate-2 (IRS2)
and a tetanus-derived peptide, with potential immunomodulating and antineoplastic
activities. Upon administration of pBCAR3/pIRS2 phosphopeptide-tetanus peptide vaccine,
the pBCAR3/pIRS2 phosphopeptide may stimulate the immune system to mount a cytotoxic
T-lymphocyte (CTL) response against tumor cells expressing either phosphopeptide.
The tetanus peptide serves as an immunoadjuvant and induces a helper T-cell response
which may help stimulate an immune response against pBCAR3 and pIRS2-expressing melanoma
tumor cells. BCAR3 and IRS2 are upregulated in a variety of cancer cells.;