Preferred Label : Autologous KRAS G12D-specific HLA-C*08:02-restricted TCR Gene Engineered T-lymphocytes
NT-112;
NCIt synonyms : Autologous Anti-KRAS G12D TCR-expressing T-cells NT-112; Autologous KRAS G12D-targeting TCR-T NT-112;
NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express
a T-cell receptor (TCR) specific for the human leukocyte antigen (HLA)-C*08:02-restricted
oncogenic K-RAS (KRAS) substitution mutation G12D, with potential antineoplastic activity.
Upon isolation, transduction, expansion ex vivo and re-introduction into the patient,
the autologous KRAS G12D-specific HLA-C*08:02-restricted TCR gene engineered T-lymphocytes
NT-112 target and bind to KRAS G12D-expressing tumor cells, resulting in cytotoxic
T-lymphocyte (CTL)-mediated killing of KRAS-G12D-expressing tumor cells. KRAS, a member
of the RAS family of oncogenes, serves an important role in cell signaling, division
and differentiation. Mutations of KRAS may induce constitutive signal transduction
leading to tumor cell proliferation, invasion, and metastasis.;
Molecule name : NT-112; NT 112;
NCI Metathesaurus CUI : CL1926381;
Origin ID : C204099;
UMLS CUI : C5908023;
Semantic type(s)
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
