NCIt related terms : Tumor Infiltrating Lymphocyte Therapy;
NCIt definition : A preparation of cells, consisting of autologous tumor infiltrating lymphocytes, that
are manipulated in vitro and, upon administration in vivo, re-infiltrate the tumor
to initiate tumor cell lysis. In vitro, therapeutic tumor-infiltrating lymphocytes
(TILs) are isolated from tumor tissue and cultured with lymphokines such as interleukin-2;
the therapeutic TILs are then infused into the patient, where, after re-infiltration
of the tumor, they may induce lysis of tumor cells and tumor regression. The use of
therapeutic TILs is considered a form of adoptive immunotherapy.;