ADA Transduced T Cell

Preferred Label : ADA Transduced T Cell;

NCIt synonyms : ADA Transduced T-Cell;

NCIt definition : T cells harvested from a patient with adenosine deaminase (ADA) deficiency and transduced with a vector containing the gene for ADA. ADA catalyzes the hydrolysis of adenosine to inosine; ADA deficiency causes a form of severe combined immunodeficiency (SCID). Following genetic modification, the T cells are returned to the patient, where they produce functional ADA. ADA-transduced T cells have been shown to improve immune function in individuals with ADA deficiency. (NCI04);

Details

Origin ID

C28797;

UMLS CUI

C1510684;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]

Keyword's position in hierarchy(ies) :

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