" /> Autologous CD19-targeted CAR-T Cells GC007F - CISMeF





Preferred Label : Autologous CD19-targeted CAR-T Cells GC007F;

NCIt synonyms : CD19 FasT CAR-T Cells GC007F; GC007F CAR-T Cells; FasTCAR-19; Autologous Anti-CD19-CAR-T Cells GC007F; FasT CAR-19; Autologous CAR-T Cells GC007F;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19 coupled to as of yet not fully elucidated co-stimulatory molecules, with potential immunostimulating and antineoplastic activities. Upon transfusion, autologous CD19-targeted CAR-T cells GC007F target and bind to CD19-expressing neoplastic B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells, the release of cytotoxic molecules and the induction of tumor cell lysis. CD19, cluster of differentiation 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. The processing platform used, FasT (F) CAR-T, shortens the manufacturing time to produce the CAR-T cells within 24 hours.;

Molecule name : GC 007F; GC-007F;

NCI Metathesaurus CUI : CL1405323;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
12/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.