Preferred Label : Autologous KRAS G12D Mutant-specific HLA-C*08:02-/KRAS G12D Mutant-specific HLA-A*11:01-/KRAS
G12V Mutant-specific HLA-C*01:02-/TP53 R175H Mutant-specific HLA-A*02:01-restricted
TCR Genes Engineered T-lymphocytes;
NCIt synonyms : Autologous HLA-C*08:02 KRAS G12D/HLA-A*11:01 KRAS G12D-/HLA-C*01:02 KRAS G12V/HLA-A*02:01
TP53 R175H-specific TCRs-expressing T-cells; Autologous KRAS G12D/KRAS G12V/P53 R175H TCR-transduced T-cells;
NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express
a T-cell receptor (TCR) specific for the human leukocyte antigen (HLA)-C*08:02-restricted
oncogenic K-RAS (KRAS) substitution mutation G12D, a TCR specific for the HLA-A*11:01-restricted
KRAS G12D, a TCR specific for the HLA-C*01:02-restricted KRAS G12V, and a TCR specific
for the HLA-A*02:01-restricted oncogenic TP53 (p53) substitution mutation R175H, with
potential antineoplastic activity. Upon isolation of peripheral blood lymphocytes
(PBLs), transduction, expansion ex vivo and re-introduction into the patient, the
autologous KRAS G12D mutant-specific HLA-C*08:02-/KRAS G12D mutant-specific HLA-A*11:01-/KRAS
G12V mutant-specific HLA-C*01:02-/TP53 R175H mutant-specific HLA-A*02:01-restricted
TCR genes engineered T-lymphocytes target and bind to tumor cells expressing the mutants
KRAS G12D, KRAS G12V and/or TP53 R175H, resulting in cytotoxic T-lymphocyte (CTL)-mediated
killing of KRAS G12D, KRAS G12V and/or TP53 R175H-expressing tumor cells. KRAS, a
member of the RAS family of oncogenes, serves an important role in cell signaling,
division and differentiation. Mutations of KRAS may induce constitutive signal transduction
leading to tumor cell proliferation, invasion, and metastasis. p53, a tumor suppressor
gene, is mutated in many tumor cells, resulting in the loss of apoptosis regulation
and abnormal cell proliferation.;
Origin ID : C212035;
chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
