Autologous CD8 SLC45A2-specific T Lymphocytes

Preferred Label : Autologous CD8 SLC45A2-specific T Lymphocytes;

NCIt synonyms : Autologous SLC45A2-specific CTLs; Autologous SLC45A2-specific Cytotoxic T Lymphocytes;

NCIt definition : A preparation of autologous CD8 T lymphocytes targeting SLC45A2, a melanoma-associated antigen, with potential immunomodulating and antineoplastic activities. Following peripheral blood mononuclear cell (PBMC) collection and ex vivo expansion of SLC45A2-specific cytotoxic T-lymphocytes (CTLs), the autologous CD8 SLC45A2-specific CTLs are re-infused into the patient, where they target and lyse SLC45A2-expressing tumor cells. While SLC45A2 is expressed by approximately 80% of cutaneous melanomas, its expression is limited in mature normal melanocytes, allowing high tumor selectivity and reduced potential for autoimmune toxicity.;

NCI Metathesaurus CUI : CL554229;

Details

Origin ID

C153083;

UMLS CUI

C4727012;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Membrane-Associated Transporter Protein [NCIt concept]

Keyword's position in hierarchy(ies) :

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