Preferred Label : Anti-NY-ESO-1 TCR LV-transduced Autologous T-Cells TAEST16001;
NCIt synonyms : Anti-NY-ESO-1 TCR Transduced Autologous T Cells TAEST16001; NY-ESO-1 Antigen Specific Affinity-enhanced TCR Transduced Autologous T Cells;
NCIt definition : A preparation of human autologous T-lymphocytes that are transduced with a lentiviral
vector (LV) encoding an affinity-enhanced T-cell receptor (TCR) specific for the cancer-testis
antigen NY-ESO-1, with potential immunostimulating and antineoplastic activities.
Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient,
the anti-NY-ESO-1 TCR LV-transduced autologous T-cells TAEST16001 recognize and bind
to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte
(CTL)-mediated killing of NY-ESO-1-positive tumor cells. NY-ESO-1, a tumor-associated
antigen (TAA), is found in normal testis and on the surface of various tumor cell
types, and is not, or is minimally, expressed in normal, healthy cells.;
Molecule name : TAEST16001; TAEST 16001;
NCI Metathesaurus CUI : CL545051;
Origin ID : C147135;
UMLS CUI : C4687729;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
