CD137L/Epstein-Barr Virus-Targeting Autologous Dendritic Cell Vaccine

Preferred Label : CD137L/Epstein-Barr Virus-Targeting Autologous Dendritic Cell Vaccine;

NCIt synonyms : CD137L-DC-EBV-VAX; CD137L/Epstein-Barr Virus-Targeting Autologous DC Vaccine;

NCIt definition : A cell-based cancer vaccine composed of in vitro generated, highly potent, CD137 ligand (CD137L)-dendritic cells (CD137L-DCs), pulsed with Epstein-Bar Virus (EBV) antigen peptides, with potential antineoplastic and immunostimulatory activities. Upon administration, CD137L-DCs induce potent CD8 T-cell responses against EBV target cells. DCs stimulated with CD137L enhance cytotoxic T-lymphocyte proliferation and activation to a greater extent compared to non-CD137L-stimulated DCs.;

NCI Metathesaurus CUI : CL554356;

Details

Origin ID

C153097;

UMLS CUI

C4727019;

Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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