Autologous CD8 Positive PBL Sensitized to Drosophila Cell-Presented Melanoma Peptides

Preferred Label : Autologous CD8 Positive PBL Sensitized to Drosophila Cell-Presented Melanoma Peptides;

NCIt synonyms : Autologous CD8 PBL Sensitized To Drosophila Cell-Presented Melanoma Peptides; Drosophila-peptide Pulsed Melanoma-reactive Autologous CD8 PBLs;

NCIt definition : A preparation of autologous CD8 (cytotoxic) human peripheral blood lymphocytes (PBLs) sensitized to Drosophila cell-presented melanoma peptides, with potential immunostimulating and antineoplastic activities. Autologous CD8 T-lymphocytes, isolated from a melanoma patient, are exposed in vitro to melanoma peptide-pulsed HLA-A2-expressing Drosophila cells, expanded, and reintroduced into the patient; these tumor-reactive T-cells may stimulate a host immune response against tumor cells expressing the melanoma antigens, resulting in tumor cell lysis. Drosophila cells, which do not express any native MHC molecules, have been shown to potently stimulate tumor-reactivity in vitro from human peripheral blood lymphocytes (PBL) when stably transfected with human MHC molecules and appropriate adhesion and costimulatory molecules.;

NCI Metathesaurus CUI : CL428179;

Détails

Origin ID

C95715;

UMLS CUI

C2987368;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

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