Autologous TAAs-loaded Autologous Dendritic Cells AV-GBM-1

Preferred Label : Autologous TAAs-loaded Autologous Dendritic Cells AV-GBM-1;

NCIt synonyms : Neoantigen-loaded Autologous Dendritic Cells AV-GBM-1; Autologous Dendritic Cells Loaded With Autologous Tumor Associated Antigens; Autologous TAAs-loaded Autologous DCs AV-GBM-1;

NCIt definition : A preparation of autologous dendritic cells (DCs) loaded with immunogenic tumor-associated antigens (TAAs) derived from cultured autologous glioblastoma multiforme (GBM) tumor cells, with potential immunostimulatory and antineoplastic activities. Upon administration, the autologous TAA-loaded DCs AV-GBM-1 expose the immune system to the GBM neoantigens, which results in a cytotoxic T-lymphocyte (CTL)-mediated immune response against the autologous GBM cells leading to GBM cell lysis.;

Molecule name : AV-GBM-1; AV GBM 1;

NCI Metathesaurus CUI : CL555286;

Details

Origin ID

C154285;

UMLS CUI

C4727558;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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