Preferred Label : Autologous Enhanced NY-ESO-1 TCR Engineered T-cells GSK4427296;
NCIt synonyms : NY-ESO-1-specific TCR T-cells GSK4427296; Stemlike NY-ESO-1-targeting TCR T Cells GSK4427296; Autologous NY-ESO-1 TCR T-cells GSK4427296;
NCIt definition : A preparation of human autologous engineered T-lymphocytes that express an affinity-enhanced
T-cell receptor (TCR) specific for the cancer-testis antigen 1 (NY-ESO-1; New York
esophageal antigen-1), with potential immunostimulating and antineoplastic activities.
Upon administration, autologous enhanced NY-ESO-1 TCR engineered T-cells GSK4427296
recognize and bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific
cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive tumor cells. NY-ESO-1,
a tumor-associated antigen (TAA) and member of the cancer-testis antigen (CTA) family,
is found in normal testis and on the surface of various tumor cell types, and is not,
or is minimally, expressed in normal, healthy cells. The TCR T-cells are manufactured
and expanded using specific epigenetic reprogramming (Epi-R) technology with continuous
NY-ESO-1 antigen exposure and stimulation to alter the phenotypic T-cell profile.
This allows for the creation of more CD8-positive stem-like T-cells, thereby increasing
stemness properties which could potentially improve T-cell function, and increase
T-cell proliferation, functional persistence, metabolic fitness, self-renewal, and
enhance durable anti-tumor responses.;
Molecule name : GSK 4427296; LYL 132; GSK-4427296; LYL-132;
NCI Metathesaurus CUI : CL1798629;
Origin ID : C189798;
UMLS CUI : C5706543;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
