" /> Autologous Anti-GPC2-CAR T-cells - CISMeF





Preferred Label : Autologous Anti-GPC2-CAR T-cells;

NCIt synonyms : Autologous GPC2 CAR T-cells; Anti-GPC2-CAR Autologous T Lymphocytes; GPC2-targeted CAR Autologous T Cells; Anti-GPC2 CAR Autologous T Cells; Autologous Anti-GPC2 CAR-T Cells; Autologous Glypican-2-specific CAR T Cells;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-2 (GPC2), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-GPC2-CAR T-cells specifically target and bind to GPC2-expressing tumor cells, resulting in tumor cell lysis. GPC2, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed in normal, healthy cells.;

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15/05/2024


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