NCIt definition : A preparation of autologous tumor-infiltrating lymphocytes (TILs) where the programmed
cell death protein 1 (PD-1; PDCD1; CD279; programmed death-1) gene has been disrupted
using transcription activator-like effector nuclease (TALEN), with potential immunomodulating
and antineoplastic activities. The autologous TILs are isolated from an autologous
tumor sample, expanded ex-vivo and genetically modified to inactivate PD-1. Upon administration,
the autologous PD-1-knockout TILs IOV-4001 induce a T-cell-mediated immune response
against tumor cells. Expression of PD-1, an inhibitory receptor expressed on activated
T-cells, plays a key role in cytotoxic T-lymphocyte (CTL) suppression, T-cell exhaustion
and CTL apoptosis. PD-1 knockout may abrogate T-cell exhaustion and increase T-cell
activity and cytotoxicity.;