Autologous PRAME-targeting TCR-modified T Cells MDG1011

Preferred Label : Autologous PRAME-targeting TCR-modified T Cells MDG1011;

NCIt synonyms : Autologous TCR Modified T Cells MDG1011; Autologous Anti-PRAME-TCR-expressing T Cells MDG1011; Autologous PRAME TCR Modified T Cells MDG1011; PRAME-TCR Gene Modified Autologous T Cells MDG1011;

NCIt definition : Human autologous T-lymphocytes transduced with a retroviral vector encoding a human leukocyte antigen (HLA)-A*02:01-restricted T-cell receptor (TCR) specific for the human tumor-associated antigen (TAA) preferentially expressed antigen in melanoma (PRAME) coupled to the CD3 signaling complex, with potential antineoplastic activity. Upon reintroduction into the patient, the autologous PRAME-targeting TCR-modified T cells MDG1011 target and bind to tumor cells expressing PRAME. This may induce cell death in and halt the growth of PRAME-expressing tumor cells. The TAA PRAME is overexpressed by a variety of cancer cell types.;

Molecule name : MDG 1011; MDG-1011;

NCI Metathesaurus CUI : CL562856;

Details

Origin ID

C156136;

UMLS CUI

C4733675;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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