Arlocabtagene Autoleucel

Preferred Label : Arlocabtagene Autoleucel;

NCIt synonyms : Autologous Anti-GPRC5D CAR-T Cells CC-95266; Autologous Anti-GPRC5D CAR T-cells BMS-986393; GPRC5D-targeted Autologous CAR T Cells BMS-986393;

NCIt definition : A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human G-protein coupled receptor family C group 5 member D (GPRC5D), with potential immunostimulating and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, arlocabtagene autoleucel specifically recognizes and induces selective toxicity in GPRC5D-expressing tumor cells. GPRC5D is overexpressed in certain malignancies, such as multiple myeloma, while minimally expressed in normal, healthy cells. It plays a key role in tumor cell proliferation.;

UNII : WQ79GLJ8VP;

Molecule name : BMS 986393; CC-95266; CC 95266; BMS-986393;

NCI Metathesaurus CUI : CL1922178;

Details

Origin ID

C203057;

UMLS CUI

C5908948;

Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- G-Protein Coupled Receptor Family C Group 5 Member D [NCIt concept]

Keyword's position in hierarchy(ies) :

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