Preferred Label : Arlocabtagene Autoleucel;
NCIt synonyms : Autologous Anti-GPRC5D CAR-T Cells CC-95266; Autologous Anti-GPRC5D CAR T-cells BMS-986393; GPRC5D-targeted Autologous CAR T Cells BMS-986393;
NCIt related terms : Autologous Anti-GPRC5D CAR-T Cells BMS-986393;
NCIt definition : A preparation of autologous T-lymphocytes engineered to express a chimeric antigen
receptor (CAR) specific for the tumor-associated antigen (TAA) human G-protein coupled
receptor family C group 5 member D (GPRC5D), with potential immunostimulating and
antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion
ex vivo, and reintroduction into the patient, the autologous anti-GPRC5D CAR-T cells
BMS-986393 specifically recognize and induce selective toxicity in GPRC5D-expressing
tumor cells. GPRC5D is overexpressed in certain malignancies, such as multiple myeloma,
while minimally expressed in normal, healthy cells. It plays a key role in tumor cell
proliferation.;
UNII : WQ79GLJ8VP;
Molecule name : BMS 986393; CC-95266; CC 95266; BMS-986393;
NCI Metathesaurus CUI : CL1922178;
Origin ID : C203057;
UMLS CUI : C5908948;
Semantic type(s)
- concept_is_in_subset
- has_target
