Autologous Anti-CD19 DASH CAR-T Cells

Preferred Label : Autologous Anti-CD19 DASH CAR-T Cells;

NCIt synonyms : CD19 DASH CAR-T Cells; CD19 Targeted DASH CAR-T Cells; Autologous Anti-CD19 DASH CAR T Cells;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified and transduced with a gamma-retrovirus vector expressing a second-generation chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 DASH CAR-T cells target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in B-cell lineage malignancies.;

NCI Metathesaurus CUI : CL1906221;

Details

Origin ID

C199282;

chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
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- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
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- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- B-Lymphocyte Antigen CD19 [NCIt concept]

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