NCIt definition : Autologous human peripheral blood lymphocytes (PBLs) transduced with a retroviral
vector encoding an anti-Her-2 (epidermal growth factor receptor 2) chimeric T cell
receptor (chimeric antigen receptor or CAR) gene with potential immunostimulatory
and antineoplastic activities. Autologous PBLs from a patient with Her-2-positive
cancer are pulsed with a retroviral vector that encodes the CAR gene specific for
Her-2. After expansion in culture and reintroduction into the patient, anti-Her-2-CAR
retroviral vector-transduced autologous peripheral blood lymphocytes, which express
anti-Her-2-CAR on their cell surfaces, bind to Her-2 antigen on tumor cell surfaces.
Subsequently, Her-2-expressing tumor cells may be lysed. Her-2 (ErbB-2), a receptor
tyrosine kinase (RTK) overexpressed by a variety of cancer cell types, belongs to
the EGFR superfamily and plays key roles in both tumor cell proliferation and tumor
angiogenesis.;