Recombinant Vaccinia-TRICOM Vaccine

Preferred Label : Recombinant Vaccinia-TRICOM Vaccine;

NCIt synonyms : Vaccinia-TRICOM;

NCIt related terms : vaccinia-TRICOM vaccine; rV-TRICOM;

NCIt definition : A vaccine consisting of recombinant vaccinia virus encoding a TRIad of COstimulatory Molecules (B7-1, ICAM-1, and LFA-3; also called TRICOM). Vaccination with recombinant vaccinia-TRICOM vaccine stimulates the host immune system to mount a non-specific T-cell response. With the addition of a tumor-associated antigen peptide, this vaccine may enhance a tumor-specific immune response.;

Alternative definition : NCI-GLOSS: A cancer vaccine made with a form of a vaccinia virus that does not cause disease in humans. It is being studied in the treatment of some types of cancer. The virus is changed in the laboratory to make human proteins that may help immune cells in the body kill tumor cells.;

NSC code : 708039;

Codes from synonyms : CDR0000572227; CDR0000572228; CDR0000543385;

Details

Origin ID

C2685;

UMLS CUI

C1099097;

Automatic exact mappings (from CISMeF team)
- rV-Tricom [MeSH concept]
- rV-Tricom [MeSH Supplementary Concept]
Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- rV-Tricom [MeSH concept]
- rV-Tricom [MeSH Supplementary Concept]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Gene Regulation Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Sargramostim/Vaccinia-MUC-1 Vaccine/Vaccinia-TRICOM Vaccine [NCIt concept]
- Vaccinia-MUC-1 Vaccine/Vaccinia-TRICOM Vaccine [NCIt concept]

Keyword's position in hierarchy(ies) :

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