PAX3/FKHR Peptide Vaccine

Preferred Label : PAX3/FKHR Peptide Vaccine;

NCIt synonyms : PAX3/FKHR Fusion Peptide; PAX3 FKHR Peptide Vaccine;

NCIt related terms : PXFK; PAX3/FKHR;

NCIt definition : A synthetic peptide vaccine based on the sequences of a translocation mutation of 2 transcriptional factor genes, PAX3 and FKHR. PAX3/FKHR fusion proteins are frequently found in patients with rhabdomyosarcomas. Vaccination with PAX3/FKHR peptide may stimulate the host immune response to elicit a cytotoxic T-cell response against tumor cells that express this PAX3/FKHR fusion protein.;

NSC code : 688096;

Codes from synonyms : NSC0688096;

Details

Origin ID

C49023;

UMLS CUI

C1709388;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
has_target
- PAX3/FOXO1 Fusion Protein [NCIt concept]

Keyword's position in hierarchy(ies) :

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