Autologous NKG2D CAR-expressing T-lymphocytes ASP2802

Preferred Label : Autologous NKG2D CAR-expressing T-lymphocytes ASP2802;

NCIt synonyms : Convertible CAR T Cells ASP2802;

NCIt definition : A preparation of autologous T-lymphocytes that are genetically modified to express a chimeric antigen receptor (CAR) for a modified and inactivated form of the type II transmembrane protein human natural-killer group 2, member D receptor protein (NKG2D; KLRK1), that can be used for potential immunostimulating and antineoplastic activities upon activation in vivo. Upon infusion back into the patient, autologous NKG2D CAR-expressing T-lymphocytes ASP2802 are inert. Upon subsequent administration of MA-20 (ASP101G; MicAbody), a bispecific adaptor molecule composed of an anti-CD20 antibody linked to a UL16-binding protein (ULBP) 2 ligand, the anti-CD20 antibody moiety of MA-20 targets and binds to CD20-expressing tumor cells and the ULBP2 ligand targets and binds to the NKG2D CAR moiety of the convertible CAR T-cells ASP2802, thereby activating the inactivated CAR T-cells, which induce selective toxicity in and lysis of CD20-expressing tumor cells. The CD20 antigen, a non-glycosylated cell surface phosphoprotein, is a B-cell specific cell surface antigen expressed in B-cell lineage malignancies.;

Molecule name : ASP-2802; ASP 2802;

Details

Origin ID

C209764;

chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients