Autologous Tumor-infiltrating Lymphocytes GT307

Preferred Label : Autologous Tumor-infiltrating Lymphocytes GT307;

NCIt synonyms : Autologous TILs GT307; Autologous CRISPR-edited TILs GT307;

NCIt definition : A preparation of autologous tumor-infiltrating lymphocytes (TILs) derived from each patient's resected tumor and edited with the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) system to eliminate the expression of as of yet not elucidated immunoregulatory targets, with potential immunomodulating and antineoplastic activities. Upon administration back into the patient, autologous TILs GT307 specifically recognize and kill the patient's tumor cells. The knockout of the immunoregulatory targets may enhance the proliferation and cytokine release of the TILs.;

Molecule name : GT 307; GT-307;

Détails

Origin ID

C216088;

chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
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- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

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