HPV E6/E7-encoding Semliki Forest Virus Vaccine Vvax001

Preferred Label : HPV E6/E7-encoding Semliki Forest Virus Vaccine Vvax001;

NCIt synonyms : Vvax001 Therapeutic Cancer Vaccine; rSFVeE6,7; HPV E6/7 Semliki Forest Virus Based Cancer Vaccine;

NCIt definition : A vaccine consisting of a recombinant, attenuated, replication-incompetent form of the Semliki Forest Virus (SFV) vector encoding the viral oncoproteins E6 and E7 derived from the human papillomavirus (HPV), with potential immunomodulating and antineoplastic activities. Upon intramuscular administration, HPV E6/E7-encoding SFV vaccine Vvax001 induces expression of the E6/E7 proteins and stimulates both the innate and the adaptive immune system, resulting in a potent cytotoxic T-lymphocyte (CTL) response against and lysis of tumor cells expressing HPV E6 and E7. Oncoproteins E6 and E7 play a key role in the development of cervical intraepithelial neoplasia (CIN) and cervical carcinoma.;

Molecule name : Vvax-001; SFVeE6,7;

NCI Metathesaurus CUI : CL551130;

Details

Origin ID

C148539;

UMLS CUI

C4725113;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients