MCPyV TAg-specific Polyclonal Autologous CD8-positive T Cells - CISMeF
MCPyV TAg-specific Polyclonal Autologous CD8-positive T CellsNCIt concept
Preferred Label : MCPyV TAg-specific Polyclonal Autologous CD8-positive T Cells;
NCIt definition : A preparation of polyclonal autologous CD8 positive T-lymphocytes specific for the
Merkel cell polyomavirus (MCPyV) T antigen (TAg) with potential antineoplastic activity.
Peripheral blood lymphocytes from a Merkel cell carcinoma (MCC) patient were obtained
and antigen-specific CD8 T cells targeting a specific MCPyV TAg epitope were derived
and expanded ex vivo. Upon infusion of the MCPyV TAg-specific polyclonal autologous
CD8-positive T cell vaccine, the T cells recognize the MCPyV antigen and exert a cytotoxic
T-lymphocyte response against the MCPyV TAg-expressing MCC cells. MCPyV is expressed
in about 80% of MCC and is not expressed in normal, human tissue; the MCPyVTag oncoprotein
plays a key role in MCC survival and tumor cell proliferation.;