Recombinant Vaccinia-CEA(6D)-TRICOM Vaccine

Preferred Label : Recombinant Vaccinia-CEA(6D)-TRICOM Vaccine;

NCIt synonyms : Vaccinia-CEA-TRICOM Vaccine; rV-CEA(6D)-TRICOM;

NCIt definition : A vaccine consisting of recombinant vaccinia virus encoding the tumor-associated antigen carcinoembryonic antigen (CEA) and a TRIad of COstimulatory Molecules (B7-1, ICAM-1, and LFA-3; also called TRICOM). Vaccination with recombinant vaccinia-CEA(6D)-TRICOM vaccine stimulates the host immune system to mount a T-cell response against tumor cells expressing the CEA antigen. The use of TRICOM in the vaccine may elicit a greater antitumor cytotoxic T lymphocyte (CTL) immune response compared to the use of vaccinia-CEA alone.;

NSC code : 710067;

Details

Origin ID

C2619;

UMLS CUI

C0935789;

Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Gene Regulation Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Carcinoembryonic Antigen [NCIt concept]
is_component_of_chemotherapy_regimen
- Fowlpox-CEA-TRICOM Vaccine/Sargramostim/Vaccinia-CEA-TRICOM Vaccine [NCIt concept]
- Fowlpox-CEA-TRICOM Vaccine/Vaccinia-CEA-TRICOM Vaccine [NCIt concept]
- Sargramostim/Vaccinia-CEA-TRICOM Vaccine [NCIt concept]

Keyword's position in hierarchy(ies) :

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