ESO-1 Reactive Autologous Peripheral Blood Lymphocyte

Preferred Label : ESO-1 Reactive Autologous Peripheral Blood Lymphocyte;

NCIt definition : Human peripheral blood lymphocytes (PBL) isolated from a patient, exposed to the tumor-associated protein ESO-1 in vitro, and then transferred back to the same patient to target tumor cells expressing ESO-1. ESO-1 is a human self-antigen expressed by melanomas. The ESO-1 gene encodes several MHC class I- and MHC class II-restricted epitopes that may activate cytotoxic T-cell-mediated tumor destruction. (NCI04);

NSC code : 729232;

Details

Origin ID

C38119;

UMLS CUI

C1512137;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
has_target
- Cancer/Testis Antigen 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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