NCIt definition : Autologous human T-lymphocytes transduced with a retroviral vector encoding an anti-epidermal
growth factor receptor (EGFR) chimeric T cell receptor (chimeric antigen receptor
or CAR) gene coupled to the signaling domains from both CD3 zeta and CD137 (4-1BB),
with potential immunostimulatory and antineoplastic activities. Upon administration,
the chimeric EGFR antigen receptor-modified autologous T lymphocytes bind to the EGFR
antigen on tumor cell surfaces; subsequently, EGFR-expressing tumor cells may be lysed.
Following binding to EGFR, the 4-1BB co-stimulatory molecule signaling domain enhances
both activation and signaling. Inclusion of the 4-1BB signaling domain may also increase
the antitumor activity when compared to the inclusion of the CD3-zeta chain alone.
EGFR, a receptor tyrosine kinase (RTK) overexpressed by a variety of cancer cell types,
plays key roles in tumor cell proliferation and tumor angiogenesis.;