Preferred Label : ECT204 Transgene-transduced Autologous T Cells ECT204;
NCIt synonyms : ECT204 T-cells; ECT204 Artemis (R) T Cells;
NCIt definition : A preparation of autologous human T-lymphocytes transduced with a lentiviral vector
expressing the ECT204 transgene that encodes an antibody-based antigen-binding domain
targeting the tumor-associated antigen (TAA) glypican-3 (GPC3) and an effector-binding
domain, with potential immunomodulating and antineoplastic activities. Following leukapheresis,
isolation of lymphocytes, expansion ex vivo, transduction, and re-introduction into
the patient, the ECT204 transgene-transduced autologous T cells ECT204 target and
bind to tumor cells expressing GPC3. This results in cytotoxic T-lymphocyte (CTL)-mediated
elimination of GPC3-positive tumor cells. GPC3, a heparan sulfate proteoglycan and
a member of the glypican family, is overexpressed on certain tumor cell types while
minimally expressed on normal, healthy cells. GPC3 plays an important role in cellular
proliferation and differentiation.Compared to conventional CAR T-cells, ECT204 may
be less likely to stimulate cytokine release syndrome (CRS) and other cytokine-mediated
toxicities.;
Molecule name : ECT-204; ECT 204;
NCI Metathesaurus CUI : CL1663395;
Origin ID : C180673;
UMLS CUI : C5556547;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
