NCIt definition : A preparation of autologous T-lymphocytes that has been genetically engineered to
express a fully humanized, universal, second generation chimeric antigen receptor
(CAR) with a CD28/CD3zeta co-stimulatory domain, and a binding domain that can recognize
a peptide motive of an antigen-specific targeting module (TM), with potential immunomodulating
and antineoplastic activities. Upon administration, autologous universal CAR-expressing
T-lymphocytes UniCAR02-T remain inactivated. Upon administration of an antigen-specific
TM, the binding domain of UniCAR02-T binds to the nuclear antigen motif of the TM,
and UniCAR02-T is activated when the antigen-binding moiety of the TM binds to the
specific antigen expressed on tumor cells. This induces selective toxicity in and
causes lysis of tumor cells expressing the specific antigen.;