Autologous HIV Gag-specific CD4 T-cells AGT103-T

Preferred Label : Autologous HIV Gag-specific CD4 T-cells AGT103-T;

NCIt synonyms : Autologous HIV-specific CD4 T Cells AGT103-T; Autologous HIV Gag-specific CD4-positive T-lymphocytes AGT103-T;

NCIt definition : A preparation of autologous, human immunodeficiency virus (HIV) Gag-specific, cluster of differentiation 4 (CD4)-positive T-lymphocytes, with potential antiviral activity. Autologous HIV Gag-specific CD4 T-cells AGT103-T are prepared via ex vivo stimulation of autologous peripheral blood mononuclear cells (PBMCs) with Gag peptides, and the Gag-specific CD4 T-cells are transduced with the recombinant lentiviral vector AGT103 encoding inhibitory RNA targeting the HIV coreceptor C-C chemokine receptor type 5 (CCR5) and HIV sequences within the Vif/Tat coding regions. Upon administration, autologous HIV Gag-specific CD4 T-cells AGT103-T may prevent infection by CCR5- or CXCR4-tropic strains of HIV, reduce the depletion of CD4 T-cells upon HIV exposure and prevent latently-infected cells from releasing new HIV particles.;

Molecule name : AGT103-T;

NCI Metathesaurus CUI : CL1771136;

Details

Origin ID

C182458;

UMLS CUI

C5666887;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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