Toll-Like Receptor 7

Preferred Label : Toll-Like Receptor 7;

NCIt synonyms : TLR7; Toll-Like Receptor-7; Toll-Like Receptor 7-Like;

NCIt definition : Toll-like receptor 7 (1049 aa, 121 kDa) is encoded by the human TLR7 gene. This protein plays a role in the response to single-stranded RNA.;

NCIt note : Toll-like receptor 7 likely acts via MyD88 (TIR interaction) and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.;

Details

Origin ID

C30108;

UMLS CUI

C0971207;

Currated CISMeF NLP mapping
- Toll-Like receptor 7 [MeSH concept]
- toll-like receptor 7 [MeSH Descriptor]
OMIM relation
- Toll-like receptor 7 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- TLR7 protein, human [MeSH concept]
- TLR7 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- TLR7 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Endoplasmic Reticulum [NCIt concept]
- Membrane of the Endosome [NCIt concept]
- Membrane of the Lysosome [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Leucine-Rich Repeat [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Dendritic Cell Pathway [NCIt concept]
- Toll-Like Receptor Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Antiviral Response [NCIt concept]
- Immune Response Process [NCIt concept]
- Ligand Binding [NCIt concept]
- RNA Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
is_target
- Enpatoran [NCIt concept]
- Guretolimod [NCIt concept]
- Hydrogel-based Resiquimod STM-416 [NCIt concept]
- Nanoparticles Encapsulating TLR7 Agonist 1v270 MBS8 [NCIt concept]
- PEG-conjugated TLR7/8 Agonist NKTR-262 [NCIt concept]
- Resiquimod [NCIt concept]
- Resiquimod Hydrogel-based Sustained-release formulation [NCIt concept]
- Resiquimod Topical Gel [NCIt concept]
- TLR Agonist BDB001 [NCIt concept]
- TLR7 Agonist ANA773 Tosylate [NCIt concept]
- TLR7 Agonist APR003 [NCIt concept]
- TLR7 Agonist LHC165 [NCIt concept]
- TLR7 Agonist SHR2150 [NCIt concept]
- TLR7 agonist BNT411 [NCIt concept]
- Telratolimod [NCIt concept]
- Toll-like Receptor 7/8 Agonist BDB018 [NCIt concept]

Keyword's position in hierarchy(ies) :

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