Preferred Label : Resiquimod Topical Gel;
NCIt synonyms : R848 Gel;
NCIt definition : A topical gel containing the Toll-like receptor (TLR) agonist resiquimod, an imidazoquinolinamine
and with potential immunomodulating activity. Resiquimod binds toTLR7 and 8, mainly
on dendritic cells, macrophages, and B-lymphocytes, and activates the TLR signaling
pathway, resulting in the induction of the nuclear translocation of transcription
activator NF-kB and activation of other transcription factors; subsequently, gene
expression increases and the production of cytokines increases, especially interferon-alpha
(INF-a), resulting in the enhancement of T-helper 1 (Th1) immune responses. In addition,
topical application of resiquimod appears to activate epidermal Langerhans cells,
leading to an enhanced activation of T-lymphocytes.;
NCI Metathesaurus CUI : CL412435;
Origin ID : C88259;
UMLS CUI : C2981783;
Semantic type(s)
- concept_is_in_subset
- has_target
