Toll-Like Receptor 8

Preferred Label : Toll-Like Receptor 8;

NCIt synonyms : TLR8; CD288 Antigen; Toll-Like Receptor-8; CD288;

NCIt definition : Toll-like receptor 8 (1041 aa, 120 kDa) is encoded by the human TLR8 gene. This protein is involved in the regulation of antimicrobial responses.;

NCIt note : Toll-like receptor 8 likely acts via MyD88 (TIR interaction) and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.;

Details

Origin ID

C30109;

UMLS CUI

C0962444;

Currated CISMeF NLP mapping
- Toll-Like receptor 8 [MeSH concept]
- toll-like receptor 8 [MeSH Descriptor]
OMIM relation
- Toll-like receptor 8 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- TLR8 protein, human [MeSH concept]
- TLR8 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- TLR8 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_gene_product_variant
- TLR8 NP_619542.1:p.N515H [NCIt concept]
- TLR8 Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Leucine-Rich Repeat [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Toll-Like Receptor Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Immune Response Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
is_target
- Enpatoran [NCIt concept]
- Hydrogel-based Resiquimod STM-416 [NCIt concept]
- Motolimod [NCIt concept]
- PEG-conjugated TLR7/8 Agonist NKTR-262 [NCIt concept]
- Resiquimod [NCIt concept]
- Resiquimod Hydrogel-based Sustained-release formulation [NCIt concept]
- Resiquimod Topical Gel [NCIt concept]
- TLR Agonist BDB001 [NCIt concept]
- TLR8 Agonist DN1508052 [NCIt concept]
- Telratolimod [NCIt concept]
- Toll-like Receptor 7/8 Agonist BDB018 [NCIt concept]

Keyword's position in hierarchy(ies) :

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