Toll-like Receptor 7/8 Agonist BDB018

Preferred Label : Toll-like Receptor 7/8 Agonist BDB018;

NCIt synonyms : TLR 7/8 Agonist BDB018;

NCIt definition : A toll-like receptor type 7 and 8 (TLR 7/8) agonist, with potential immunostimulating and antitumor activities. Upon administration, TLR 7/8 agonist BDB018 binds to and activates TLR7 and 8, thereby activating TLR7/8-mediated pathways. This stimulates the maturation and activation of antigen-presenting cells (APCs), including dendritic cells (DCs). Activation of DCs results in the production of pro-inflammatory cytokines, and the activation of cytotoxic T-lymphocyte (CTL)- and B-lymphocyte-mediated immune responses. This may lead to tumor cell lysis. TLR7 and 8, members of the TLR family, play fundamental roles in the activation of the innate immune system, myeloid cell responses and tumor antigen presentation.;

Molecule name : BDB-018; BDB 018;

NCI Metathesaurus CUI : CL1662949;

Details

Origin ID

C180587;

UMLS CUI

C5556479;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Toll-Like Receptor 7 [NCIt concept]
- Toll-Like Receptor 8 [NCIt concept]

Keyword's position in hierarchy(ies) :

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