Preferred Label : TLR8 Agonist DN1508052;
NCIt synonyms : TLR8 Agonist DN1508052-01; TLR8 Agonist DN-A1;
NCIt definition : A small molecule Toll-like receptor 8 (TLR8; CD288) agonist with potential immunostimulating
and antineoplastic activities. Upon subcutaneous administration, TLR8 agonist DN1508052
binds to TLR8, which is expressed in myeloid dendritic cells (mDCs), monocytes, and
natural killer (NK) cells. This may lead to the activation of nuclear factor NF-kappa-B,
the release of proinflammatory cytokines and a Th1-weighted anti-tumor immune response.
Additionally, activation of TLR8 signaling in tumor cells may block the induction
and reverse the suppression of senescent naive and tumor-specific T-cells, resulting
in enhanced anti-tumor immunity. TLR8, like other TLRs, recognizes pathogen-associated
molecular patterns (PAMPs) and plays a key role in innate and adaptive immunity.;
Molecule name : DN1508052-01; DN A1; DN-1508052; DN-A1;
NCI Metathesaurus CUI : CL969563;
Origin ID : C160500;
UMLS CUI : C5205308;
Semantic type(s)
- concept_is_in_subset
- has_target
