Preferred Label : Resiquimod;
NCIt synonyms : 4-Amino-2-(ethoxymethyl)-alpha,alpha-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol;
NCIt definition : An imidazoquinolinamine and Toll-like receptor (TLR) agonist with potential immune
response modifying activity. Resiquimod exerts its effect through the TLR signaling
pathway by binding to and activating TLR7 and 8 mainly on dendritic cells, macrophages,
and B-lymphocytes. This induces the nuclear translocation of the transcription activator
NF-kB as well as activation of other transcription factors. This may lead to an increase
in mRNA levels and subsequent production of cytokines, especially interferon-alpha
(INF-a) and other cytokines, thereby enhancing T-helper 1 (Th1) immune responses.
In addition, topical application of resiquimod appears to activate Langerhans' cells,
leading to an enhanced activation of T-lymphocytes. Due to its immunostimulatory activity,
this agent may potentially be useful as a vaccine adjuvant.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of skin cancer.
When put on the skin, resiquimod causes some immune cells to make certain chemicals
that may help them kill tumor cells. It is also being studied to find out if adding
it to a tumor vaccine improves the antitumor immune response. It is a type of imidazoquinoline
and a type of immunomodulator.;
UNII : V3DMU7PVXF;
InChIKey : BXNMTOQRYBFHNZ-UHFFFAOYSA-N;
CAS number : 144875-48-9;
Molecule name : S 28463; R848;
Chemical formula : C17H22N4O2;
ChEBI ID : CHEBI:36706;
Codes from synonyms : 50685; CDR0000557354;
Origin ID : C63958;
UMLS CUI : C0965594;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
