NCIt definition : A toll-like receptor (TLR) agonist with potential immunostimulating and antineoplastic
activities. Upon administration, TLR agonist BDB001 activates one or more not yet
disclosed TLRs, which may result in macrophage and plasmacytoid dendritic cell (pDC)
stimulation; secretion of interferon alpha (IFNa); production of proinflammatory cytokines;
upregulation of co-stimulatory molecules; enhanced T- and B-cell stimulatory responses;
T-cell proliferation; and a T-helper 1 (Th1) immune response. TLRs are transmembrane
receptors that recognize structurally conserved microbial molecules such as bacterial
cell-surface lipopolysaccharides (LPS), lipoproteins, lipopeptides, lipoarabinomannan
and flagellin, among others; immune responses stimulated by TLR activation may result
in immune-mediated tumor cell killing.;
Semantic type(s)