" /> Toll-like Receptor 7/8 Agonist EIK1001 - CISMeF





Preferred Label : Toll-like Receptor 7/8 Agonist EIK1001;

NCIt synonyms : Toll-like Receptor Agonist BDB001; TLR Agonist BDB001; TLR7/8 Agonist EIK1001;

NCIt definition : A toll-like receptor type 7 and 8 (TLR7/8) agonist, with potential immunostimulating and antineoplastic activities. Upon administration, TLR7/8 agonist EIK1001 targets, binds to and activates TLR7 and 8, thereby activating TLR7/8-mediated pathways. This stimulates the maturation and activation of antigen-presenting cells (APCs), including dendritic cells (DCs). Activation of DCs results in the production of pro-inflammatory cytokines, and the activation of cytotoxic T-lymphocyte (CTL)- and B-lymphocyte-mediated immune responses. This may lead to tumor cell lysis. TLR7 and 8, members of the TLR family, play fundamental roles in the activation of the innate immune system, myeloid cell responses and tumor antigen presentation.;

Molecule name : BDB-001; BDB 001; EIK 1001; EIK-1001;

NCI Metathesaurus CUI : CL563098;

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03/07/2025


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