Preferred Label : Enpatoran;
NCIt synonyms : TLR 7/8 Antagonist M5049; TLR 7/8 Inhibitor M5049;
NCIt definition : An orally bioavailable toll-like receptor type 7 and 8 (TLR 7/8) dual antagonist,
with potential anti-inflammatory and immunomodulating activities. Upon oral administration,
enpatoran binds to and inhibits the activity of TLR7 and 8, thereby inhibiting TLR7/8-mediated
pathways. This may inhibit the production of pro-inflammatory cytokines, and block
the activation of immune responses. TLR7 and 8, members of the TLR family, play fundamental
roles in the activation of the innate immune system, myeloid cell responses and tumor
antigen presentation.;
UNII : 7CZ390V26X;
InChIKey : BJXYHBKEQFQVES-NWDGAFQWSA-N;
CAS number : 2101938-42-3;
Molecule name : M 5049; M-5049;
NCI Metathesaurus CUI : CL1642847;
Origin ID : C177069;
UMLS CUI : C5447563;
Semantic type(s)
- concept_is_in_subset
- has_target
