Telratolimod - CISMeF

Preferred Label : Telratolimod;

NCIt synonyms : Toll-like Receptor 7/8 Agonist MEDI9197; TLR7/TLR8 Dual Agonist MEDI9197;

NCIt definition : A toll-like receptor type 7 and 8 (TLR7/8) agonist with potential immunostimulating and antitumor activities. Upon intratumoral administration, telratolimod binds to and activates TLR7 and 8, thereby stimulating antigen-presenting cells (APCs), including dendritic cells (DCs). Activation of DCs results in the production of proinflammatory cytokines, and the activation of cytotoxic T-lymphocyte (CTL) and B-lymphocyte immune responses. This may cause tumor cell lysis. TLR7 and 8, members of the TLR family, play fundamental roles in the activation of the immune system.;

UNII : 16598XQ2BT;

InChIKey : RRTPWQXEERTRRK-UHFFFAOYSA-N;

CAS number : 1359993-59-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1359993-59-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : MEDI 9197; 3M-052; 3M 052; MEDI-9197;

NCI Metathesaurus CUI : CL502885;

Details

Origin ID

C124653;

UMLS CUI

C4086987;

Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MEDI9197 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Toll-Like Receptor 7 [NCIt concept]
- Toll-Like Receptor 8 [NCIt concept]

Keyword's position in hierarchy(ies) :

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