Preferred Label : TLR7/8 Agonist BM201;
NCIt synonyms : SR TLR7/8 Agonist BM201; Sustained-release TLR7/8 Agonist BM201; Extended-release TLR7/8 Agonist BM201; ER TLR7/8 Agonist BM201;
NCIt definition : An extended-release (ER) microparticle formulation of toll-like receptor type 7 and
8 (TLR 7/8) agonist, with potential immunostimulating and antitumor activities. Upon
administration, TLR7/8 agonist BM201 targets, binds to and activates TLR7 and 8, thereby
activating TLR7/8-mediated pathways. This stimulates the maturation and activation
of antigen-presenting cells (APCs), including dendritic cells (DCs). Activation of
DCs results in the production of pro-inflammatory cytokines and the activation of
cytotoxic T-lymphocyte (CTL)- and B-lymphocyte-mediated immune responses. This may
lead to tumor cell lysis. TLR7 and 8, members of the TLR family, play fundamental
roles in the activation of the innate immune system, myeloid cell responses and tumor
antigen presentation.;
Molecule name : BM-201; BM 201;
Origin ID : C215091;
concept_is_in_subset
- has_target
