NCIt definition : A small-molecule Toll-like receptor 8 (TLR8) agonist with potential immunostimulating
and antineoplastic activities. Motolimod binds to TLR8, present in cutaneous dendritic
cells, monocytes/macrophages, and mast cells, which may result in the activation of
the central transcription factor nuclear factor-B, the secretion of proinflammatory
cytokines and other mediators, and a Th1-weighted antitumoral cellular immune response.
Primarily localized to endosomal membranes intracellularly, TLR8, like other TLRs,
recognizes pathogen-associated molecular patterns (PAMPs) and plays a key role in
the innate immune system.;
UNII : WP6PY72ZH3;
InChIKey : QSPOQCXMGPDIHI-UHFFFAOYSA-N;
CAS number : 926927-61-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 926927-61-9
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Automatic exact mappings (from CISMeF team)