NCIt definition : A small-molecule Toll-like receptor 8 (TLR8) agonist with potential immunostimulating
and antineoplastic activities. Motolimod binds to TLR8, present in cutaneous dendritic
cells, monocytes/macrophages, and mast cells, which may result in the activation of
the central transcription factor nuclear factor-B, the secretion of proinflammatory
cytokines and other mediators, and a Th1-weighted antitumoral cellular immune response.
Primarily localized to endosomal membranes intracellularly, TLR8, like other TLRs,
recognizes pathogen-associated molecular patterns (PAMPs) and plays a key role in
the innate immune system.;
Automatic exact mappings (from CISMeF team)