Preferred Label : TLR7/8 Agonist INI-4001;
NCIt synonyms : Toll-like Receptor 7/8 Agonist INI-4001;
NCIt definition : A lipidated toll-like receptor type 7 and 8 (TLR 7/8) agonist, with potential immunoadjuvating,
immunostimulating and antitumor activities. Upon administration, TLR7/8 agonist INI-4001
targets, binds to and activates TLR7 and 8, thereby activating TLR7/8-mediated pathways.
This stimulates the maturation and activation of antigen-presenting cells (APCs),
including dendritic cells (DCs). Activation of DCs results in the production of pro-inflammatory
cytokines and the activation of cytotoxic T-lymphocyte (CTL)- and B-lymphocyte-mediated
immune responses. This may lead to tumor cell lysis. TLR7 and 8, members of the TLR
family, play fundamental roles in the activation of the innate immune system, myeloid
cell responses and tumor antigen presentation.;
Molecule name : INI 4001; INI-4001;
Origin ID : C207265;
concept_is_in_subset
- has_target
